Arcalion forte 30 tablets
Servier
Servier
Composition
Each tablet contains
Sulbutiamine 400mg
Auxiliary components
Starch, anhydrous glucose, lactose monohydrate, magnesium stearate, talc, hypromellose, microcrystalline cellulose, riboflavin, propylene glycol.
Properties
Sulbutiamine is an original compound obtained from thiamine by a number of structural modifications of the thiamine nucleus: the formation of a disulfide bond, the introduction of a lipophilic ester, and the opening of the thiazole ring.
Thanks to this modification, sulbutiamine
well soluble in fats, which allows it to be quickly absorbed from the gastrointestinal tract and easily penetrate the BBB;
is able to accumulate in the cells of the retic formation, the hippocampus and the dentate gyrus, as well as the cells of Purkinje fibers and the glomeruli of the granular layer of the cerebellar cortex, which is confirmed by histochemical analysis.
Sulbutiamine is metabolized to thiamine (vitamin B 1). In combination with adenosine triphosphate (ATP), thiamine forms thiamine diphosphate (carboxylase or thiamine pyrophosphate), which takes part in carbohydrate metabolism as a coenzyme.
Indications
Fatigue in adults, accompanied by increased fatigue, decreased performance, weakness.
Method of administration and dosage
The daily dose of the drug
1 tablet with breakfast.
The tablets should be swallowed whole with water.
The duration of treatment should not excee weeks.
Do not exceed the recommended dose and duration of the drug.
The patient should be warned that if the condition worsens or does not improve after 4 weeks, consult a doctor.
Contraindications
– age up to 18 years (due to lack of clinical data);
-pregnancy;
-the period of breastfeeding;
-lactase deficiency, galactosemia, glucosegalactose malabsorption syndrome, sucroseisomaltase deficiency, fructose intolerance, due to the content of glucose, lactose and sucrose in the preparation as excipients;
hypersensitivity to the active substance (sulbutiamine) or any of the components of drug.
Precautionary measures
Influence on the ability to drive vehicles and mechanisms
Care should be taken when driving a car and performing work that requires a high speed of psychomotor reactions, taking into account the possible development of adverse reactions.
Side effects
tremor, headache, agitation, malaise;
-nausea, vomiting;
allergic reactions (rash).
Storage method
In a cool dry place at a temperature not exceeding 25 degrees.
Packaging
The cardboard box contains 2 blisters of 15 tablets.