Gast-Reg 200 mg 30 tablets
Amoun Pharmaceutical Co.S.A.E
Amoun Pharmaceutical Co.S.A.E
Composition
Each tablet contains
Trimebutine maleate 200 mg.
Excipients
Lactose monohydrate (Lactopress) (milk sugar), pregelatinized starch (Starch 1500), colloidal silicon dioxide (Aerosil), magnesium stearate, talc.
Properties
Trimebutine acts on the enkephalinergic system of the intestine and regulates gastrointestinal motility. By acting on peripheral δ-, μ-, and κ-receptors, including those directly located on the smooth muscles throughout the gastrointestinal tract (GIT), it normalizes motility without affecting the central nervous system. Thus, trimebutine restores the normal physiological activity of intestinal muscles in various gastrointestinal disorders associated with motility disturbances.
By normalizing visceral sensitivity, trimebutine also provides analgesic effects in cases of abdominal pain syndrome.
Indications
For oral administration
Symptomatic treatment of pain associated with functional disorders of the gastrointestinal and biliary tract.
For parenteral use
Symptomatic treatment of severe pain due to functional GIT disorders;
Treatment of postoperative paralytic ileus;
Preparation for radiological and endoscopic examinations.
Dosage and Administration
The optimal dosing regimen is determined by the physician. The specific dosage form used must match the indicated use and dosage instructions.
Individual dosage
Daily dose for oral use — up to 300 mg (one 100 mg tablet 3 times per day).
The dose can be increased up to 600 mg per day (one 200 mg tablet 3 times per day).
Contraindications
Hypersensitivity to trimebutine.
Pregnancy.
Lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Precautions
A course of treatment for irritable bowel syndrome at a dose of 600 mg/day for four weeks during the acute phase, followed by 300 mg/day for 12 weeks, helps prevent recurrence of the condition.
Adverse Reactions
Gastrointestinal: dry mouth, unpleasant taste, diarrhea, dyspepsia, nausea, constipation.
Nervous system: drowsiness, fatigue, dizziness, headache, restlessness, sensation of heat or cold.
Allergic reactions: skin rash.
Others: menstrual disorders, painful breast enlargement, urinary retention.
Storage Conditions
Store in a dry place at temperatures not exceeding 25°C.
Packaging
A cardboard box containing 1, 2, or 3 blister packs of 10 tablets each, and a paper insert (instructions for use).