Augmentin 1 g 14 tablets
Composition
each tablet contains
amoxicillin 875 mg clavulanic acid 125mg
Auxiliary components: magnesium stearate
14.5 mg, sodium carboxymethyl starch 29 mg, colloidal silicon dioxide – 10 mg, microcrystalline cellulose – 243.16 mg.
Properties
Amoxicillin is a semi-synthetic penicillin
(beta-lactam antibiotic) that inhibits one or
more enzymes (known as penicillin-binding proteins) in the biosynthesis of bacterial peptidoglycan, which is the unifying structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to a thinning of the cell wall, which subsequently leads to lysis and cell death. Amoxicillin is destroyed by the action of lactamases produced by resistant bacteria, and therefore the spectrum of activity of amoxicillin itself does not include microorganisms that produce these enzymes.
Clavulanic acid is a lactamase inhibitor structurally related to penicillins. Clavulanic acid blocks the action of certain lactamase enzymes, thereby preventing the inactivation of amoxicillin. Clavulanic acid alone does not show a clinically significant antibacterial effect.
Indications
Augmentin is indicated for the treatment of the following infections in adults and children:
Dental infections (eg periodontitis, maxillary
sinusitis, severe dental abscesses with spreading cellulitis) – for tablets 500 mg / 125 mg or 875 mg / 125 mg;
Acute bacterial sinusitis
Acute otitis media
Exacerbations of chronic bronchitis
Community-acquired pneumonia
Cystitis
Pyelonephritis
Skin and soft tissue infections, in particular phlegmon, animal bites, severe dental abscess with spreading phlegmon.
Bone and joint infections, particularly osteomyelitis
Official guidelines for the rational use of antibacterial agents should be taken into account.
Method of administration and dosage
For optimal absorption and to reduce possible side effects from the digestive system, Augmentin® is recommended to be taken at the beginning of a meal.
The dosage regimen is set individually, depending on the severity of the course and localization of the infection, the sensitivity of the pathogen.
Augmentin tablets should not be taken by children under 12 years of age.
Recommended dose for adults and children over 12 years of age: Tablets 875 mg + 125 mg should be used only in patients with CC> 30 ml / min, and no dosage adjustment is required.
The recommended dose is one tablet every 12 hours.
The minimum course of antibiotic therapy is 5 days.
Treatment should not continue for more than 14 days without revising the clinical situati
Contraindications
impaired renal function (CC s30 ml / min) – (for tablets 875 mg / 125 mg), hypersensitivity to amoxicillin, clavulanic acid, other components of the drug, betalactam antibiotics (for example, penicillins, cephalosporins) in anamnesis; previous episodes of jaundice or impaired liver function when using a combination of amoxicillin with clavulanic acid in history.
Precautionary measures
Before starting treatment with Augmentin®, it is necessary to collect a detailed history of previous hypersensitivity reactions to penicillins, cephalosporins or other substances that cause an allergic reaction in the patient.
Serious and sometimes fatal hypersensitivity reactions (anaphylactic reactions) to penicillins have been described. The risk of such reactions is highest in patients with a history of hypersensitivity reactions to penicillins. In the event of an allergic reaction, it is necessary to discontinue treatment with Augmentin® and begin an appropriate alternative therapy.
Side effects
Infectious and parasitic diseases: often – candidiasis of the skin and mucous membranes.
From the digestive tract
– adults: very often – diarrhea; often – nausea, vomiting; – children: often – diarrhea, nausea, vomiting;
Adverse events from the liver are observed mainly in men and elderly patients and may be associated with long-term therapy. These adverse events are very rare in children.
Storage method
In a cool dry place
Packaging
Cardboard box holds 2 blisters of 7 tablets