Coversyl Plus 10/2.5 mg 15 tablets
Composition
Each tablet contains
Perindopril arginine 10 mg.
Indapamide 2.5 mg.
Excipients: lactose monohydrate, magnesium stearate, maltodextrin, sodium glycodal, glycerol, hypromellose, macrogol, titanium dioxide.
Product Description
Coverseal Plus is a combined antihypertensive agent that enhances the effect of each component.
Indapamide: a sulfonamide derivative with properties similar to thiazide diuretics. It inhibits sodium reabsorption in the cortical segment of the loop of Henle, increasing excretion of sodium, chloride, and to a lesser extent potassium and magnesium, thereby enhancing diuresis and lowering blood pressure.
Perindopril: an ACE inhibitor that blocks the conversion of angiotensin I to angiotensin II, reduces aldosterone secretion, increases plasma renin activity, and decreases total peripheral resistance. It improves myocardial function by reducing preload and afterload.
Indications for Use
Essential hypertension.
Hypertension in patients with type 2 diabetes mellitus to reduce the risk of microvascular (renal) and macrovascular (cardiovascular) complications.
Method of Administration and Dosage
Oral administration.
1 tablet daily, preferably in the morning before meals.
In elderly patients, use only with normal renal function and monitor blood pressure reduction.
Contraindications
Indapamide
Hypersensitivity to indapamide or sulfonamides.
Severe renal impairment (CrCl < 30 ml/min).
Hepatic encephalopathy, severe hepatic impairment.
Hypokalemia.
Concomitant use with non‑antiarrhythmic drugs that may cause torsades de pointes.
Lactation, age under 18 years.
Perindopril
Hypersensitivity to ACE inhibitors.
Angioedema (including hereditary/idiopathic).
Pregnancy, lactation.
Concomitant use with angiotensin II receptor antagonists in diabetic nephropathy.
Concomitant use with valsartan + sacubitril.
Extracorporeal therapy with negatively charged surfaces.
Bilateral renal artery stenosis or stenosis of a solitary kidney.
Age under 18 years.
Precautions
Combination therapy may increase risk of idiosyncratic reactions; careful monitoring is required.
Does not significantly reduce adverse effects compared to individual components, except for hypokalemia.
Adverse Effects
Perindopril: dizziness, headache, paresthesia, dysgeusia, visual disturbances, vertigo, tinnitus, hypotension, cough, dyspnea, abdominal pain, constipation, dyspepsia, diarrhea, nausea, vomiting, pruritus, rash, muscle cramps, asthenia.
Indapamide: hypersensitivity reactions, mainly cutaneous, in predisposed patients; maculopapular rash.
Pregnancy and Lactation
Contraindicated.
Storage Conditions
Store at temperatures not exceeding 30 °C.
Packaging
Carton box containing 15 tablets and paper insert.