Vibramycin 100 mg 10 capsules
Composition
Each capsule contains
Doxycycline Hyclate 100 mg
Auxiliary components
calcium stearate, lactose monohydrate, potato starch.
The composition of the hard gelatin capsule: gelatin, glycerin, purified water, titanium dioxide, sodium lauryl sulfate, dyes: quinoline yellow (E-104), orange yellow (E-110).
Properties
Semi-synthetic antibiotic of the tetracyclines group of broad spectrum of action. It has a bacteriostatic effect by suppressing the protein synthesis of pathogens.
Active against aerobic gram-positive bacteria
Staphylococcus spp. (including strains
producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Bacillus anthracis, Listeria monocytogenes; anaerobic bacteria: Clostridium spp.
Doxycycline is also active against aerobic gram-negative bacteria: Neisseria gonorrhoeae, Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Bordetella pertussis, as well as against Rickettsia spp., Treponema spp., Treponema spp. and Chlamydia spp.
Pseudomonas aeruginosa, Proteus spp., Serratia spp., Most strains of Bacteroides fragilis are resistant to doxycycline.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to doxycycline, incl. respiratory and upper respiratory tract infections; gastrointestinal infections; purulent infections of the skin and soft tissues
(including acne); infections of the genitourinary system (including gonorrhea, primary and secondary syphilis); typhus, brucellosis, rickettsioses, osteomyelitis, trachoma, chlamydia.
Method of administration and dosage
The recommended daily dose is 200 mg, 1 capsule every 12 hours, on the first day of treatment. After 1 capsule per day.
The course of treatment is on average 10 days, depending on the indications.
Contraindications
Pregnancy, children under 8 years of age (the possibility of the formation of insoluble complexes with calcium in the bone skeleton, enamel and dentin of the teeth), hypersensitivity to tetracyclines, porphyria, severe liver failure, leukopenia, lactation period, myasthenia gravis (for intravenous administration).
Precautions
Doxycycline is used with caution in case of liver dysfunction. In case of impaired renal function, dose adjustment is not required.
To prevent local irritation (esophagitis, gastö gastrointestinal tract ulceration), it is recommended to take it in the daytime with a large amount of liquid, food or milk. In connection with the possible development of photosensitivity, it is necessary to limit insolation during treatment and for 4-5 days after it.
Doxycycline is not used in children under 8 years of age, because tetracyclines (including doxycycline) cause long-term discoloration of teeth, enamel hypoplasia and a slowdown in the longitudinal growth of skeletal bones in this category of patients.
Side effects
From the digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dysphagia, glossitis, esophagitis, a transient increase in the blood levels of hepatic transaminases, alkaline phosphatase, bilirubin.
From the hematopoietic system: neutropenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: skin rash, itching, eosinophilia; rarely – Quincke’s edema, photosensitivity.
)others: an increase in residual nitrogen,
:andidiasis, intestinal dysbiosis, discoloration teeth in children.
Storage method
At a temperature not exceeding 30 g. In a dry 31 ace.
Packaging
The cardboard box contains 2 blisters of 5 capsules, paper instructions.