Zyrovazet 10 mg/40 mg 30 tablets
Composition
Each tablet contains
Rosuvastatin — 40 mg;
Ezetimibe — 10 mg.
Excipients: microcrystalline cellulose, lactose monohydrate, povidone K30, poloxamer 407, sodium lauryl sulfate, sodium croscarmellose, magnesium stearate
Product Description
Zirovazet is a lipid‑lowering medicine combining rosuvastatin and ezetimibe.
It is used in adults to reduce total cholesterol, LDL cholesterol, and triglycerides, while increasing HDL cholesterol.
It works through a dual mechanism: rosuvastatin inhibits cholesterol synthesis in the liver, and ezetimibe blocks cholesterol absorption in the intestine.
Indications for Use
As adjunct to diet for reduction of elevated total cholesterol and LDL cholesterol.
As adjunct to diet for patients with elevated triglycerides.
In patients with cardiovascular disease, to reduce LDL cholesterol to < 100 mg/dL.
Homozygous familial hypercholesterolemia.
Method of Administration and Dosage
Take as directed by a physician.
Recommended dose: 1 tablet daily, with or without food.
Dose is individualized depending on treatment goals and patient response.
No dose adjustment required in renal impairment.
Not recommended in patients with hepatic dysfunction.
Contraindications
Hypersensitivity to rosuvastatin or ezetimibe.
Severe liver disease.
Pregnancy and breastfeeding.
Precautions
Use with caution when co‑administered with erythromycin (may increase plasma rosuvastatin levels).
Caution in patients with liver disease or alcohol abuse.
Discontinue temporarily if polymyositis symptoms or rhabdomyolysis occur.
Use cautiously with drugs affecting steroid hormone levels (ketoconazole, spironolactone, cimetidine).
Do not use in patients with hereditary lactose intolerance.
Women of childbearing potential should use only when pregnancy is excluded and risks are understood.
Adverse Effects
Upper respiratory tract infections.
Headache, stress.
Muscle and back pain.
Sinusitis.
Diarrhea, abdominal pain.
Pregnancy and Lactation
Contraindicated.
Not to be used during pregnancy or breastfeeding.
Storage Conditions
Store at temperatures not exceeding 30 °C, in a dry place, out of reach of children.
Packaging
Cardboard box containing 3 blisters of 10 film‑coated tablets, with patient information leaflet.