Erastapex Plus 40 mg/12.5 mg 30 tablets
Apex Pharma
Apex Pharma
Composition
One tablet contains
Olmesartan medoxomil 40 mg
Hydrochlorothiazide 12.5 mg
Auxiliary components
Lactose, colodial silicone dioxide, starch, magnesium stearate, talc, titanium dioxide.
Properties
Erastapex plus is a combination drug that includes an angiotensin II receptor antagonist (olmesartan medoxomil) and a thiazide diuretic (hydrochlorothiazide). The combination of two active substances has a combined antihypertensive effect, as a result of which blood pressure decreases to a greater extent than when each of them is taken separately. When taking the drug once a day, an effective and uniform decrease in blood pressure is achieved within 24 hours.
Indications
– essential arterial hypertension (with the ineffectiveness of olmesartan medoxomil monotherapy).
Method of administration and dosage
The recommended dose is 1 tablet per day.
Contraindications
– hereditary lactose intolerance, lack of lactase in the body or malabsorption syndrome of glucose and lactose;
-severe liver dysfunction (more than 9 points on the Child-Pugh scale) (risk of developing hepatic coma), obstruction of the biliary tract and cholestasis;
-severe renal dysfunction (CC less than 30 ml / min.);
-refractory hypokalemia, hyponatremia, hypercalcemia and symptomatic hyperuricemia;
-pregnancy;
– lactation period;
– age up to 18 years (the effectiveness and safety of the drug have not been studied);
– hypersensitivity to olmesartan medoxomil, hydrochlorothiazide or other sulfonamide derivatives or to any of the excipients that make up the drug.
Precautionary measures
Symptomatic arterial hypotension, especially after taking the first dose of the drug, can occur in patients with reduced BCC and / or reduced sodium concentration due to intensive diuretic therapy, restriction of salt intake with food during dietary meals, and also due to diarrhea or vomiting. The relevant factors should be eliminated before using Erastapex plus.
Thiazide diuretics, including hydrochlorothiazide, can cause disturbances in the BCC or serum water and electrolyte balance (including hypokalemia, hyponatremia, and hypochloremic alkalosis). Precursor symptoms are: dryness of the oral mucosa, thirst, weakness, drowsiness, anxiety, myalgia or cramps, muscle weakness, hypotension, oliguria, tachycardia, nausea and vomiting.
Side effects
From the side of the central nervous system
Often: dizziness.
Uncommon: syncope.
On the part of the cardiovascular system
Infrequently: palpitations, marked decrease in blood pressure, orthostatic hypotension.
From the side of the skin
Uncommon: skin rash, eczema.
From the side of metabolism
Uncommon: hyper- or hypokalemia, hypercalcemia, hypertriglyceridemia, hyperuricemia, increased blood lipids.
On the part of laboratory parameters
Very rare: a slight increase in the concentration of creatinine, uric acid and urea nitrogen in the blood serum, a slight decrease in the concentration of hemoglobin and hematocrit.
Storage method
At a temperature not higher than 30 degrees. In a dry place.
Package
The cardboard box holds 3 blisters of 10 tablets.