Tenormin 25 mg 28 tablets
AstraZeneca
AstraZeneca
Composition
Each tablet contains:
Atenolol 25 mg.
Product Description
Tenormin is a cardioselective β₁-adrenoceptor blocking agent acting predominantly on the heart.
It reduces heart rate and myocardial contractility, decreases myocardial oxygen demand and lowers blood pressure, thereby reducing cardiac workload. It is used in the treatment of hypertension, angina pectoris, cardiac arrhythmias, and for early and late intervention following myocardial infarction to reduce morbidity and mortality.
Indications for Use
Hypertension;
Angina pectoris;
Cardiac arrhythmias;
Myocardial infarction (early and late intervention).
Method of Administration and Dosage
Dosage should be adjusted individually, starting with the lowest effective dose.
Hypertension:
Usually one tablet daily.
Most patients respond to 100 mg once daily, some patients respond to 50 mg once daily.
Full therapeutic effect is established within 1–2 weeks.
Tenormin may be combined with other antihypertensive agents, including diuretics.
Angina pectoris:
100 mg once daily or 50 mg twice daily.
Additional benefit from higher doses is unlikely.
Cardiac Arrhythmias:
Oral maintenance dose: 50–100 mg once daily.
Myocardial Infarction:
Early intervention (within 12 hours): 5–10 mg by slow intravenous injection.
Followed by 50 mg orally after 15 minutes, then 50 mg after 12 hours, followed by 100 mg once daily.
Late intervention: 100 mg orally once daily for long-term prophylaxis.
Elderly:
Dose reduction may be required, particularly in patients with impaired renal function.
Renal Impairment:
CrCl > 35 ml/min - no dose adjustment required, CrCl 15–35 ml/min - 50 mg daily, CrCl < 15 ml/min - 25 mg daily or 50 mg on alternate days.
Haemodialysis - 50 mg orally after each dialysis under supervision.
Contraindications
Hypersensitivity to atenolol or excipients;
Bradycardia (< 45 bpm);
Cardiogenic shock;
Hypotension;
Metabolic acidosis;
Severe peripheral arterial circulatory disturbances;
Second or third degree AV block;
Sick sinus syndrome;
Untreated phaeochromocytoma;
Uncontrolled heart failure.
Precautions
Do not withdraw abruptly; taper dose over 7–14 days.
Discontinue at least 24 hours prior to planned surgery.
May increase frequency and duration of Prinzmetal’s angina.
May mask symptoms of hypoglycaemia and thyrotoxicosis.
May increase severity of allergic reactions and reduce response to adrenaline.
Use with caution in first-degree AV block.
Reduce dose if resting heart rate falls below 50–55 bpm.
Use with caution in elderly patients.
Use with caution in patients with obstructive airways disease.
In phaeochromocytoma, administer with an alpha-blocker.
Dose adjustment required in renal impairment.
Side Effects
Common: bradycardia, cold extremities, fatigue.
Rare / Very rare: dizziness, headache, sleep disturbances, mood changes, gastrointestinal disturbances, skin reactions, psoriasis exacerbation, bronchospasm, impotence, elevated liver enzymes.
Pregnancy and Lactation
Use only if the potential benefit outweighs the possible risk.
Tenormin crosses the placenta and is excreted in breast milk.
Neonates may be at risk of bradycardia and hypoglycaemia.
Storage Conditions
Do not store above 25 °C.
Protect from light and moisture.
Keep out of reach of children.
Packaging
Carton box containing blisters (28 tablets total) and insert leaflet.