Avara 20 mg 30 tablets
Sanofi Egypt
Sanofi Egypt
Composition
Active ingredient
Leflunomide — 20 mg.
Pharmacological properties
Immunosuppressive action — suppresses T-lymphocyte activity.
Anti-inflammatory action — reduces the production of pro-inflammatory cytokines.
Prevents progression of joint damage.
Improves functional status and mobility of joints.
Indications for use
Rheumatoid arthritis (RA) — active form.
Psoriatic arthritis (PsA) — as prescribed by a physician.
Dosage and administration
Loading dose
May include a loading dose of 100 mg for 3 days.
Maintenance dose
For rheumatoid arthritis — 10 or 20 mg once daily, depending on disease severity;
For psoriatic arthritis — 20 mg once daily.
Tablets are taken orally, after meals or regardless of food intake, with water.
The effect develops gradually — within 4–6 weeks, with the maximum effect achieved within 3–6 months.
Side effects
Common
Nausea, diarrhea, headache, increased blood pressure.
Rare
Alopecia, rash, increased liver enzyme activity, dizziness.
Very rare
Toxic epidermal necrolysis, Stevens-Johnson syndrome.
If side effects occur, it is recommended to consult a physician.
Contraindications
Hypersensitivity to leflunomide or any components of the medication.
Severe liver and kidney impairment.
Pregnancy and breastfeeding.
Children and adolescents under 18 years of age.
Severe blood disorders.
Special warnings and precautions
Regular monitoring of liver function and blood parameters is required.
Women of childbearing age should use effective contraception.
The medication is contraindicated during pregnancy and breastfeeding.
Dizziness may occur — caution is advised when driving and operating machinery.
Storage conditions
Store in a dry place at a temperature not exceeding 25°C.
Keep out of reach of children.
Packaging
30 tablets per blister pack.