Megamox 625 mg 14 tablets
Hikma Pharmaceuticals
Hikma Pharmaceuticals
Compound
Each tablet contains
Amoxicillin 500 mg
Clavulanic acid 125 mg
Auxiliary components
Anhydrous colloidal, sodium gluconate, microcrystalline cellulose, magnesium stearate.
Properties
Combined preparation of amoxicillin and clavulanic acid, a beta-lactamase inhibitor. It acts bactericidal, inhibits the synthesis of the bacterial wall.
Active against aerobic gram-positive bacteria (including beta-lactamase producing strains).
Clavulanic acid inhibits II, III, IV and V types of beta-lactamases, is not active against type I beta-lactamases produced by Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high affinity for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases.
Indications
Treatment of infectious and inflammatory diseases caused by susceptible pathogens: infections of the lower respiratory tract (bronchitis, pneumonia, pleural empyema, lung abscess); infections of ENT organs (sinusitis, tonsillitis, otitis media); infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvic peritonitis, soft chancre, gonorrhea); infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection); osteomyelitis; postoperative infections.
Dosage and administration
Children under 12 years old: 20-40 mg / kg / day in 2-3 doses.
Adults and children over 12 years of age or weighing 40 kg or more: 250-500 mg 2-3 times / day or 875 mg 2 times / day.
The maximum daily dose of amoxicillin for adults and children over 12 years old is 6 g, for children under 12 years old – 45 mg / kg of body weight.
Contraindications
Hypersensitivity to amoxicillin and other penicillins, clavulanic acid, other beta-lactam antibiotics (cephalosporins, carbapenems, monobactams);
– cholestatic jaundice and / or other abnormal liver function caused by the use of amoxicillin / clavulanic acid in history; – severe renal dysfunction (CC <30 ml / min) (for a dosage form intended for use in children from 3 months to 12 years old);
– children’s age up to 3 months. With caution
Impaired liver function, impaired renal function.
Precautionary measures
This combination is not recommended for suspected infectious mononucleosis.
During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with food.
Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.
Side effects
From the digestive system: nausea, vomiting, diarrhea, gastritis, stomatitis, glossitis, increased activity of hepatic transaminases, in isolated cases – cholestatic jaundice, hepatitis.
On the part of the hematopoietic organs: a reversible increase in prothrombin time and bleeding time, thrombocytopenia, thrombocytosis.
From the nervous system: dizziness, headache, hyperactivity, anxiety, behavioral changes, convulsions.
From the urinary system: interstitial nephritis, crystalluria, hematuria.
Allergic reactions: urticaria, erythematous rashes, rarely – erythema multiforme exudative.
Storage method
Store at a temperature not exceeding 30 degrees.
Package
The cardboard box contains 2 blisters of 7 tablets, paper instructions.
Manufacturer
Egypt