Heli Cure 14 tablets
Egyphar
Egyphar
Composition
Each tablet contains
Omeprazole — 20 mg.
Clarithromycin — 250 mg.
Tinidazole — 500 mg.
Excipients: mannitol, povidone, sodium croscarmellose, sodium lauryl sulfate, talc, magnesium stearate.
Product Description
Combined preparation for eradication therapy of Helicobacter pylori.
Omeprazole — proton pump inhibitor, reduces gastric acid secretion by blocking H+/K+‑ATPase enzyme.
Clarithromycin — macrolide antibiotic, inhibits protein synthesis in microbial cells, active against Helicobacter pylori.
Tinidazole — antimicrobial agent, damages bacterial DNA, effective against anaerobes, protozoa, and Helicobacter pylori.
Indications for Use
Eradication therapy of Helicobacter pylori in gastric and duodenal ulcer disease.
Method of Administration and Dosage
Optimal dosing regimen determined by physician.
Typically taken twice daily (morning and evening) with meals.
Average treatment course: 2 weeks.
Contraindications
Hypersensitivity to omeprazole, clarithromycin, tinidazole, or macrolides.
Concomitant use with cisapride, pimozide, astemizole, terfenadine, ethanol.
Pregnancy and breastfeeding.
Organic CNS diseases, porphyria.
Bone marrow suppression.
Pediatric use.
Renal and/or hepatic insufficiency.
Precautions
Exclude malignancy before therapy, as treatment may mask symptoms.
Use cautiously with drugs metabolized by the liver.
Monitor prothrombin time if combined with warfarin or other anticoagulants.
Avoid combination with terfenadine, cisapride, astemizole in patients with cardiac disease.
Tinidazole may cause dark urine.
Exercise caution when driving or operating machinery during therapy.
Adverse Reactions / Side Effects
Gastrointestinal: dysbiosis, diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbance, metallic taste, reduced appetite, stomatitis, elevated liver enzymes, hepatic dysfunction, hepatitis, rarely pseudomembranous colitis.
CNS: headache, dizziness, agitation, fatigue, drowsiness, insomnia, paresthesia, depression, hallucinations, seizures, psychosis, tinnitus.
Musculoskeletal: muscle weakness, myalgia, arthralgia.
Hematologic: leukopenia, neutropenia, thrombocytopenia, anemia.
Skin: itching, rash, photosensitivity, erythema multiforme, alopecia.
Allergic: urticaria, angioedema, bronchospasm, anaphylactic shock.
Other: tachycardia, interstitial nephritis, vision disturbances, peripheral edema, sweating, fever, gynecomastia.
Pregnancy and Lactation
Contraindicated.
Storage Conditions
Store at temperatures not exceeding 30 °C.
Packa ging
Carton box containing 7 blisters of 2 tablets each, with leaflet.