Tobrin 0.3% Eye ointment 5 g
Compound
Each gram of ointment contains
Tobramycin 3 mg
Auxiliary components
anhydrous chlorobutanol, mineral oil (liquid paraffin), white petrolatum.
Properties
Broad-spectrum aminoglycoside antibiotic. It has a bactericidal effect, disrupting protein synthesis and the permeability of the cytoplasmic membrane of bacteria.
Highly active against Pseudomonas aeruginosa.
Tobramycin is active against gram-negative bacteria: Escherichia coli, Proteus spp. (indole-positive and indole-negative strains), Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Shigella spp., Salmonella spp., Citrobacter spp., Haemophilus influenzae; Gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase).
Inactive against Streptococcus spp. (including Enterococcus spp.). Indications: – blepharitis – conjunctivitis – keratoconjunctivitis – blepharoconjunctivitis – keratitis – iridocyclitis.
Indications
Prevention of postoperative infectious complications in ophthalmology.
Dosage and administration
– For eye infections, apply a small amount of ointment (1-1.5 cm) into the conjunctival sac of the affected eye(s), 2-3 times a day, or in addition to drops at bedtime. As inflammation decreases, reduce the frequency of use until complete cessation.
– In acute infections of the eye, 1.5 cm of ointment in the eye or both eyes 3-4 times a day until improvement, then gradually reduce the dose until the reception is completely stopped. The course of treatment is 7-10 days.
Contraindications
Hypersensitivity to tobramycin and other aminoglycosides.
Precautionary measures
Systemic use of tobramycin is possible when the expected benefit of treatment outweighs the risk of side effects in the following cases: in patients with impaired renal function, hearing, myasthenia gravis and parkinsonism.
Side effects
From the side of the central nervous system and peripheral nervous system: ototoxic effect, headache, lethargy, disorientation, impaired neuromuscular transmission.
From the digestive system: nausea, vomiting, increased levels of hepatic transaminases and bilirubin in the blood.
From the hemopoietic system: anemia, granulocytopenia, thrombocytopenia.
From the side of metabolism: hypocalcemia, hyponatremia, hypokalemia, hypomagnesemia.
Other: possible nephrotoxic effect, allergic reactions.
Storage
Store at a temperature not higher than 15-30 degrees.
Package
The cardboard box contains a tube of 5 grams, paper instructions.
Manufacturer
EIPICO, Egypt