Xanthistop 80 mg 30 tablets
Atco pharma
Atco pharma
Compound
Each tablet contains
Febuxostat 80 mg.
Properties
Selective non-purine xanthine oxidase inhibitor, 2-aryl triazole derivative.
The enzyme xanthine oxidase catalyzes two steps of purine metabolism: the oxidation of hypoxanthine to xanthine and then the oxidation of xanthine to uric acid.
As a result of selective inhibition of xanthine oxidase (oxidized and reduced forms) by febuxostat, a decrease in the concentration of uric acid in the blood serum occurs.
The in vitro inhibition constant is less than 1 nM.
Indications
Treatment of chronic hyperuricemia in conditions accompanied by the deposition of urate crystals (in the presence of tophi and / or gouty arthritis, including a history).
Treatment and prevention of hyperuricemia in adult patients during cytostatic therapy of hemoblastoses with a moderate to high risk of developing tumor disintegration syndrome (only for a dose of 120 mg).
Dosage and administration
Taken inside.
The dose is 80-120 mg 1 time / day.
The duration of treatment is set individually, depending on the indications.
The goal of treatment is to lower and maintain serum uric acid levels below 6 mg/dL (357 µmol/L).
Contraindications
Pregnancy, breastfeeding period;
children’s age up to 18 years;
hypersensitivity to febuxostat.
Precautionary measures
Febuxostat should only be started after an acute attack of gout has resolved.
The use of febuxostat can provoke the development of an acute attack of gout due to the release of urate from tissue depots and a subsequent increase in the concentration of uric acid in the blood serum.
For the prevention of gout attacks, the simultaneous use of NSAIDs or colchicine for at least 6 months is recommended.
Side effects
From the nervous system
often – headache;
infrequently – dizziness, paresthesia, hemiparesis, drowsiness, change in taste perception, hypesthesia, hyposmia (weakening of smell).
From the endocrine system
infrequently – an increase in the concentration of TSH in the blood plasma.
From the side of metabolism
often – attacks of gout;
infrequently – diabetes mellitus, hyperlipidemia.
From the digestive system
often – diarrhea (more often with the simultaneous use of colchicine), nausea;
infrequently – abdominal pain, bloating.
From the side of the liver and biliary tract
often – a violation of liver function (more often with the simultaneous use of colchicine);
infrequently – cholelithiasis, increased activity of alkaline phosphatase, LDH in blood plasma; rarely – hepatitis, jaundice, liver damage.
On the part of the skin and subcutaneous tissues
often – a rash (including various types of rashes mentioned below with a lower frequency).
General reactions
often – edema;
infrequently – increased fatigue, chest pain.
Storage method
Store at a temperature not exceeding 30 degrees.
Package
Cardboard box contains 3 blisters of 10 tablets, paper instructions.